Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.49 |
| ▸ | IGF1R | P08069 | 5/20 | 0.49 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30010123 | 0.90 | NTRK1 (0.52) | NTRK1IGF1RRPS6KB1 | |
| SCHEMBL23217059 | 0.90 | NTRK1 (0.52) | NTRK1IGF1RRPS6KB1 | |
| SCHEMBL15209597 | 0.84 | PAK1 (0.49) | NTRK1IGF1R | |
| SCHEMBL4144541 | 0.84 | NTRK1 (0.59) | NTRK1IGF1R | |
| SCHEMBL4067495 | 0.82 | IGF1R (0.43) | NTRK1IGF1RMAPK13MAPK12MAPK11 | |
| SCHEMBL2207551 | 0.81 | IGF1R (0.38) | NTRK1IGF1RMAPK13MAPK12MAPK11 | |
| SCHEMBL2209333 | 0.81 | IGF1R (0.38) | NTRK1IGF1RMAPK13MAPK12MAPK11 | |
| SCHEMBL4075051 | 0.79 | MAPK13 (0.41) | NTRK1IGF1RMAPK13MAPK12MAPK11 | |
| SCHEMBL4162039 | 0.74 | NTRK1 (0.62) | NTRK1IGF1R | |
| SCHEMBL4469628 | 0.73 | ADORA2A (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |