Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.43 |
| ▸ | IDH1 | O75874 | 3/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | LDHB | P07195 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071743 | 0.90 | NTRK1 (0.47) | NTRK1HTR7 | |
| SCHEMBL4075051 | 0.86 | MAPK13 (0.41) | IGF1RNTRK1IDH1MAPK13MAPK12 | |
| SCHEMBL4151428 | 0.84 | NTRK1 (0.49) | IGF1RNTRK1CCNA2CDK2CCNA1 | |
| SCHEMBL4077928 | 0.82 | NTRK1 (0.49) | IGF1RNTRK1MAPK13MAPK12MAPK11 | |
| SCHEMBL4072134 | 0.81 | NTRK1 (0.48) | NTRK1HTR7 | |
| SCHEMBL2207551 | 0.77 | IGF1R (0.38) | IGF1RNTRK1NUDT1MAPK13MAPK12 | |
| SCHEMBL2209333 | 0.77 | IGF1R (0.38) | IGF1RNTRK1NUDT1MAPK13MAPK12 | |
| SCHEMBL4074269 | 0.76 | NTRK1 (0.49) | NTRK1HTR7 | |
| SCHEMBL4889103 | 0.75 | IGF1R (0.39) | IGF1RNTRK1IDH1NUDT1MAPK13 | |
| SCHEMBL4151807 | 0.74 | NTRK1 (0.54) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |