Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 13/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 8/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.38 |
| ▸ | GGT1 | P19440 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078056 | 1.00 | GRIK1 (0.44) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| 6-Diazo-5-Oxo-L-Norleucine SCHEMBL9295 | 0.80 | GSR (0.52) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| 6-Diazo-5-Oxo-L-Norleucine SCHEMBL295053 | 0.80 | GSR (0.52) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| 6-Diazo-5-Oxo-L-Norleucine SCHEMBL4281654 | 0.80 | GSR (0.52) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL3052694 | 0.77 | GSR (0.46) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Serine SCHEMBL442652 | 0.73 | SLC1A1 (0.41) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Serine SCHEMBL1253823 | 0.73 | SLC1A1 (0.41) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL4516176 | 0.73 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| SCHEMBL645887 | 0.71 | ALDH1A1 (0.33) | GRIK1GRIK2GRM1GRM2GRIA4 | |
| Azaserine SCHEMBL8861 | 0.71 | SLC1A5 (0.38) | GRIK1GRIK2GRM1GRM2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240424004-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | BIOCANIM A S (CZ) | 2024-12-26 | — | — | US | claimed |
| EP-4433056-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | Biocanim A.s. (CZ) | 2024-09-25 | — | — | EP | claimed |
| WO-2023083396-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDEJOVICÍCH (CZ) | 2023-05-19 | — | — | WO | claimed |
| WO-2009038289-A2 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING FIBROSIS | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2009-03-26 | — | — | WO | claimed |
| WO-2009038288-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CATARACT | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2009-03-26 | — | — | WO | claimed |
| US-20240424004-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | BIOCANIM A S (CZ) | 2024-12-26 | — | — | US | disclosed |
| EP-4433056-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | Biocanim A.s. (CZ) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023083396-A1 | COMBINATION OF TLR LIGANDS, COMPOUNDS LABELLING TUMORS FOR IMMUNE ATTACK, ANTI-CD40 ANTIBODIES AND INHIBITORS OF GLUTAMINE METABOLISM FOR TREATING CANCER | JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDEJOVICÍCH (CZ) | 2023-05-19 | — | — | WO | disclosed |
| WO-2009038289-A2 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING FIBROSIS | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009038288-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CATARACT | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2009-03-26 | — | — | WO | disclosed |
| US-7491410-B2 | Food grade transglutaminase inhibitor and uses thereof | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2009-02-17 | — | — | US | disclosed |
| EP-1330166-B1 | FOOD GRADE TRANSGLUTAMINASE INHIBITOR AND USES THEREOF | TNO (NL) | 2005-08-03 | — | — | EP | disclosed |
| US-20050031603-A1 | Food grade transglutaminase inhibitor and uses thereof | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2005-02-10 | — | — | US | disclosed |
| EP-1330166-A1 | FOOD GRADE TRANSGLUTAMINASE INHIBITOR AND USES THEREOF | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002035942-A1 | FOOD GRADE TRANSGLUTAMINASE INHIBITOR AND USES THEREOF | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 2002-05-10 | — | — | WO | disclosed |
| EP-1201136-A1 | Food grade transglutaminase inhibitor and uses thereof | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO (NL) | 2002-05-02 | — | — | EP | disclosed |
| WO-1999065516-A9 | METHODS AND COMPOSITIONS FOR TREATING DISEASES MEDIATED BY TRANSGLUTAMINASE ACTIVITY | YEDA RES & DEV (IL) | 2000-07-06 | — | — | WO | disclosed |
| WO-1999065516-A1 | METHODS AND COMPOSITIONS FOR TREATING DISEASES MEDIATED BY TRANSGLUTAMINASE ACTIVITY | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 1999-12-23 | — | — | WO | disclosed |