Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 1/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30706725 | 1.00 | JAK2 (0.45) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL29788341 | 0.81 | ALDH1A1 (0.53) | CYP3A4ALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL29349435 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL4112541 | 0.81 | ALDH1A1 (0.53) | CYP3A4ALDH1A1TSHRHSD17B10HPGD | |
| SCHEMBL65699 | 0.81 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL14742902 | 0.78 | ALDH1A1 (0.59) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL2638226 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Hydrochloric Acid SCHEMBL11277860 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| SCHEMBL9627127 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 | |
| Fluoride SCHEMBL11274176 | 0.78 | JAK2 (0.52) | JAK2RPS6KA3MELKSTK24CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114891199-A | Preparation method of poly (fluorophenyl ester) polymer with high dielectric constant | 西安交通大学 | 2022-08-12 | — | — | CN | claimed |
| WO-2007049124-A1 | METHOD OF MAKING 8-FLUORO-NAPHTHALEN-1-YLAMINE AND RELATED COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-05-03 | — | — | WO | claimed |
| US-20260015350-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2026-01-15 | — | — | US | disclosed |
| CN-119677749-A | Azaquinazoline pan KRAS inhibitors | 米拉蒂治疗股份有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-114891199-B | Preparation method of polyfluorophenyl ester polymer with high dielectric constant | 西安交通大学 | 2024-06-25 | — | — | CN | disclosed |
| WO-2023244615-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |
| US-20230212170-A1 | INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF | ANTENGENE DISCOVERY LIMITED (CN) | 2023-07-06 | — | — | US | disclosed |
| US-20230212170-A1 | INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF | ANTENGENE DISCOVERY LIMITED (CN) | 2023-07-06 | — | — | US | disclosed |
| US-20230212170-A1 | INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF | ANTENGENE DISCOVERY LIMITED (CN) | 2023-07-06 | — | — | US | disclosed |
| EP-4161934-A1 | INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF | ANTENGENE DISCOVERY LIMITED (CN) | 2023-04-12 | — | — | EP | disclosed |
| CN-115836072-A | Inhibitors of KRAS G12C protein and uses thereof | 上海德琪医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-1863784-B | 2-naphthylimino-1,3-thiazine derivative | SHIONOGI & CO | 2010-11-17 | — | — | CN | disclosed |
| US-7482339-B2 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2009-01-27 | — | — | US | disclosed |
| JP-2007119461-A | 8-FLUORO-NAPHTHALENE-1-YLAMINE AND RELATED COMPOUNDS | PFIZER PROD INC | 2007-05-17 | — | — | JP | disclosed |
| WO-2007049124-A1 | METHOD OF MAKING 8-FLUORO-NAPHTHALEN-1-YLAMINE AND RELATED COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007049124-A1 | METHOD OF MAKING 8-FLUORO-NAPHTHALEN-1-YLAMINE AND RELATED COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007049124-A1 | METHOD OF MAKING 8-FLUORO-NAPHTHALEN-1-YLAMINE AND RELATED COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | SHIONOGI AND CO., LTD. (JP) | 2006-12-14 | — | — | US | disclosed |
| CN-1863784-A | 2-naphthylimino-1,3-thiazine derivative | SHIONOGI & CO (JP) | 2006-11-15 | — | — | CN | disclosed |
| EP-1659117-A1 | 2-NAPHTHYLIMINO-1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2006-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281738-A1 | 2-Naphthylimino-1,3-thiazine derivative | NPM1, OXTR, CYP2S1 | JAK2 175/4885RPS6KA3 2227/4885MELK 3543/4885 |
| US-20230212170-A1 | INHIBITORS OF KRAS G12C PROTEIN AND USES THEREOF | KRAS, NRAS, HRAS | JAK2 990/4885RPS6KA3 1079/4885MELK 1120/4885 |
| US-20260015350-A1 | AZAQUINAZOLINE PAN-KRAS INHIBITORS | KRAS, NRAS, HRAS | JAK2 674/4885RPS6KA3 799/4885MELK 2599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.