Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | FABP1 | P07148 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392130 | 0.92 | SERPINE1 (0.47) | MAPTTP53SMN1; SMN2THRBSERPINE1 | |
| SCHEMBL4397313 | 0.92 | HIF1A (0.47) | MAPTTP53SMN1; SMN2THRBSERPINE1 | |
| SCHEMBL4080084 | 0.90 | SERPINE1 (0.49) | MAPTTP53SMN1; SMN2THRBSERPINE1 | |
| SCHEMBL4070333 | 0.88 | FABP1 (0.45) | FABP1SERPINE1PIK3CAPIK3CGALDH1A1 | |
| SCHEMBL4404817 | 0.86 | FABP1 (0.44) | MAPTFABP1SERPINE1PIK3CAPIK3CG | |
| SCHEMBL3961023 | 0.85 | MAPT (0.52) | MAPTTP53SMN1; SMN2THRBFABP1 | |
| SCHEMBL4067709 | 0.81 | SERPINE1 (0.49) | MAPTSMN1; SMN2SERPINE1PIK3CAALDH1A1 | |
| SCHEMBL3940645 | 0.80 | BRD4 (0.53) | MAPTTP53SMN1; SMN2THRBSERPINE1 | |
| SCHEMBL4387391 | 0.80 | MAP2 (0.42) | MAPTTP53SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4073082 | 0.79 | SERPINE1 (0.48) | MAPTSMN1; SMN2SERPINE1PIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036906-A1 | Azaindoles as inhibitors of soluble adenylate cyclase | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-03-18 | — | — | EP | disclosed |