Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392130 | 0.93 | SERPINE1 (0.47) | HIF1AEDNRAMAPTTP53THRB | |
| SCHEMBL4078804 | 0.92 | MAPT (0.47) | HIF1AMAPTTP53THRBSMN1; SMN2 | |
| SCHEMBL4080084 | 0.90 | SERPINE1 (0.49) | HIF1AKITMAPTTP53THRB | |
| SCHEMBL4072264 | 0.89 | EDNRB (0.46) | HIF1AKITEDNRBEDNRAMAPT | |
| SCHEMBL4133133 | 0.87 | HIF1A (0.53) | HIF1AKITEDNRBEDNRAMAPT | |
| SCHEMBL4067709 | 0.82 | SERPINE1 (0.49) | HIF1AMAPTSMN1; SMN2PTPN5SERPINE1 | |
| SCHEMBL3940645 | 0.81 | BRD4 (0.53) | HIF1AMAPTTP53THRBSMN1; SMN2 | |
| SCHEMBL4072263 | 0.81 | ACLY (0.48) | KITEDNRBEDNRAMAPTPTPN2 | |
| SCHEMBL4073082 | 0.80 | SERPINE1 (0.48) | HIF1AEDNRAMAPTSMN1; SMN2PTPN5 | |
| SCHEMBL4070333 | 0.80 | FABP1 (0.45) | SERPINE1POLBACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036906-A1 | Azaindoles as inhibitors of soluble adenylate cyclase | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-03-18 | — | — | EP | disclosed |