Sugi Predict

Sugi Predict / Compounds / SCHEMBL407903

SCHEMBL407903

SCHEMBL407903

FC(F)(F)c1ccc2n[c]cnc2c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.43
▸ PKM P14618 1/20 0.41
▸ BACE1 P56817 1/20 0.40
▸ PARP1 P09874 1/20 0.39
▸ EPHX2 P34913 1/20 0.38
▸ SCN4A P35499 1/20 0.38
▸ NOS3 P29474 1/20 0.36
▸ NOS2 P35228 1/20 0.36
▸ NPBWR1 P48145 2/20 0.34
▸ DYRK1A Q13627 1/20 0.34
▸ DYRK1B Q9Y463 1/20 0.34
▸ MAOB P27338 1/20 0.34
▸ CBFB Q13951 1/20 0.34
▸ PTGS1 P23219 1/20 0.33
▸ ADRB2 P07550 1/20 0.33
▸ NCF1 P14598 1/20 0.33
▸ GAK O14976 3/20 0.33
▸ PDE2A O00408 1/20 0.33
▸ PDE10A Q9Y233 1/20 0.33
▸ EGFR P00533 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL406463 0.93 KDM4E (0.43) KDM4EPKMBACE1PARP1EPHX2
SCHEMBL2306818 0.81 SCN10A (0.36) KDM4EPKMGAKRIPK2COQ8A
SCHEMBL435814 0.75 KDM4E (0.38) KDM4EPKMBACE1PARP1
SCHEMBL12502189 0.74 NOS3 (0.52) KDM4EPKMBACE1PARP1EPHX2
SCHEMBL29550395 0.74 NOS3 (0.52) KDM4EPKMBACE1PARP1EPHX2
Methane SCHEMBL28257040 0.72 NOS3 (0.50) KDM4EPKMBACE1PARP1EPHX2
SCHEMBL407851 0.71 HTT (0.38) BACE1MAOB
SCHEMBL16241815 0.70 PKM (0.45) KDM4EPKMBACE1PARP1EPHX2
SCHEMBL407917 0.70 BACE1 (0.51) KDM4EPKMBACE1EPHX2SCN4A
SCHEMBL406456 0.70 BACE1 (0.43) KDM4EPKMBACE1PARP1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP claimed
EP-2387569-B1 HERBCIDES SYNGENTA LTD (GB) 2016-06-15 — — EP claimed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 — — US claimed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 — — US claimed
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 — — WO claimed
US-11958840-B2 Compounds, compositions and methods DENALI THERAPEUTICS INC. (US) 2024-04-16 — — US disclosed
US-20230114472-A1 COMPOUNDS, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC. 2023-04-13 — — US disclosed
EP-3923935-A1 COMPOUNDS, COMPOSITIONS AND METHODS Denali Therapeutics Inc. (US) 2021-12-22 — — EP disclosed
CN-113518618-A Compounds, compositions and methods 戴纳立制药公司 2021-10-19 — — CN disclosed
US-20210292311-A1 COMPOUNDS, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC. 2021-09-23 — — US disclosed
WO-2020168011-A1 COMPOUNDS, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC. (US) 2020-08-20 — — WO disclosed
EP-2389066-B1 CYCLOPENTADIONE DERIVED HERBICIDES SYNGENTA LTD (GB) 2017-07-05 — — EP disclosed
US-8895474-B2 Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds SYNGENTA LIMITED (GB) 2014-11-25 — — US disclosed
US-8865623-B2 Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds SYNGENTA LIMITED (GB) 2014-10-21 — — US disclosed
US-8680339-B2 Herbicides SYNGENTA LIMITED (GB) 2014-03-25 — — US disclosed
WO-2013050938-A1 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2013-04-11 — — WO disclosed
US-20120028800-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-02-02 — — US disclosed
US-20120021912-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed
US-20120021909-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed
US-20120021907-A1 NOVEL HERBICIDES SYNGENTA CROP PROTECTION LLC (US) 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120021912-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 KDM4E 1092/4885PKM 2307/4885BACE1 1901/4885
US-11958840-B2 Compounds, compositions and methods EIF4EBP1, EIF4B, EIF4E KDM4E 2319/4885PKM 2229/4885BACE1 3789/4885
US-20230114472-A1 COMPOUNDS, COMPOSITIONS AND METHODS EIF4EBP1, EIF4B, EIF4E KDM4E 2319/4885PKM 2229/4885BACE1 3789/4885
US-20210292311-A1 COMPOUNDS, COMPOSITIONS AND METHODS EIF4EBP1, EIF4B, EIF4E KDM4E 2319/4885PKM 2229/4885BACE1 3789/4885
US-20120021909-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 KDM4E 1092/4885PKM 2307/4885BACE1 1901/4885
US-20120021907-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 KDM4E 1092/4885PKM 2307/4885BACE1 1901/4885
US-20120028800-A1 NOVEL HERBICIDES DDT, CYP4X1, CYP1B1 KDM4E 1092/4885PKM 2307/4885BACE1 1901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.