Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071751 | 0.95 | MAOB (0.44) | EGLN1EGLN2MAOBP2RY14ALDH1A1 | |
| SCHEMBL4071784 | 0.85 | EGLN1 (0.41) | EGLN1THRATHRBEGLN2MAOB | |
| SCHEMBL522615 | 0.83 | EGLN1 (0.55) | EGLN1THRATHRBEGLN2MAOB | |
| SCHEMBL4076022 | 0.82 | THRA (0.41) | EGLN1THRATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL4255377 | 0.80 | L3MBTL1 (0.42) | EGLN1EGLN2MAOBP2RY14ALDH1A1 | |
| SCHEMBL4069669 | 0.80 | DHODH (0.44) | EGLN1THRATHRBALDH1A1HPGD | |
| SCHEMBL522871 | 0.79 | EGLN1 (0.49) | EGLN1THRATHRBEGLN2MAOB | |
| SCHEMBL4078616 | 0.78 | EGLN1 (0.41) | EGLN1THRATHRBALDH1A1HPGD | |
| SCHEMBL4073465 | 0.78 | EGLN1 (0.49) | EGLN1THRATHRBALDH1A1HPGD | |
| SCHEMBL1509116 | 0.78 | THRA (0.75) | EGLN1THRATHRBEGLN2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |