Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081511 | 0.83 | EGLN1 (0.49) | EGLN1BBOX1FTOKDM4EALDH1A1 | |
| SCHEMBL4079442 | 0.80 | TTR (0.32) | EGLN1BBOX1FTOKDM4EMEN1 | |
| SCHEMBL4075081 | 0.78 | DHODH (0.44) | EGLN1KDM4EALDH1A1HPGDHTT | |
| SCHEMBL4069669 | 0.78 | DHODH (0.44) | EGLN1KDM4EALDH1A1HPGDHTT | |
| SCHEMBL4071751 | 0.78 | MAOB (0.44) | EGLN1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4079700 | 0.78 | EGLN1 (0.45) | EGLN1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1033035 | 0.77 | EGLN1 (0.47) | EGLN1BBOX1FTOKDM4EMEN1 | |
| SCHEMBL4078672 | 0.76 | ALDH1A1 (0.39) | EGLN1BBOX1FTOKDM4EMEN1 | |
| SCHEMBL4078616 | 0.76 | EGLN1 (0.41) | EGLN1BBOX1FTOKDM4EMEN1 | |
| SCHEMBL1033539 | 0.76 | EGLN1 (0.46) | EGLN1BBOX1FTOTHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |