Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.42 |
| ▸ | CLK2 | P49760 | 8/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | FECH | P22830 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083954 | 0.93 | CSNK1D (0.51) | CSNK1DFGFR1JAK2FGFR4NTRK1 | |
| SCHEMBL4091542 | 0.86 | CSNK1D (0.66) | CSNK1DDYRK1ACLK2GAKDYRK3 | |
| SCHEMBL4079762 | 0.85 | CSNK1D (0.74) | CSNK1DDYRK1ACLK2GAKDYRK3 | |
| SCHEMBL4084459 | 0.85 | FGFR4 (0.45) | CSNK1DFGFR1MAPK8FGFR4NTRK1 | |
| SCHEMBL4183857 | 0.85 | CSNK1D (0.65) | CSNK1DFGFR1DYRK1ACLK2GAK | |
| SCHEMBL13811900 | 0.85 | FGFR1 (0.52) | CSNK1DFGFR1DYRK1ACLK2GAK | |
| SCHEMBL4089648 | 0.84 | CSNK1D (0.64) | CSNK1DFGFR1DYRK1ACLK2GAK | |
| SCHEMBL4091326 | 0.84 | CSNK1D (0.64) | CSNK1DFGFR1DYRK1ACLK2GAK | |
| SCHEMBL5246773 | 0.84 | CSNK1D (0.68) | CSNK1DDYRK1ACLK2GAKDYRK3 | |
| SCHEMBL4094402 | 0.83 | FGFR4 (0.43) | CSNK1DFGFR1MAPK8FGFR4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065383-A1 | Indazole compounds and methods of use thereof as protein kinase inhibitors | Signal Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | BHAGWAT SHRIPAD S | 2009-04-16 | — | — | US | disclosed |
| US-20060004043-A1 | Indazole compounds and methods of use thereof | BHAGWAT SHRIPAD S | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | WNT3, WNT3A, WNK3 | CSNK1D 702/4885FGFR1 827/4885DYRK1A 461/4885 |
| US-20060004043-A1 | Indazole compounds and methods of use thereof | WNT3, WNT3A, WNK3 | CSNK1D 687/4885FGFR1 791/4885DYRK1A 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.