Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079722 | 0.93 | CSNK1D (0.60) | CSNK1DFGFR1PRKDCFGFR4JAK2 | |
| SCHEMBL13812167 | 0.85 | FGFR1 (0.48) | CSNK1DFGFR1PRKDCPIK3CAP2RY12 | |
| SCHEMBL4043167 | 0.85 | CSNK1D (0.57) | CSNK1DJAK2LRRK2ALDH1A1HSD17B10 | |
| SCHEMBL13812040 | 0.84 | CSNK1D (0.59) | CSNK1DFGFR1JAK2LRRK2 | |
| SCHEMBL4084459 | 0.83 | FGFR4 (0.45) | CSNK1DFGFR1FGFR4L3MBTL1NTRK1 | |
| SCHEMBL4084969 | 0.83 | CSNK1D (0.55) | CSNK1DJAK2LRRK2ALDH1A1HSD17B10 | |
| SCHEMBL4079354 | 0.83 | CSNK1D (0.58) | CSNK1DFGFR1PIK3CAJAK2 | |
| SCHEMBL13812033 | 0.82 | CSNK1D (0.57) | CSNK1DJAK2LRRK2ALDH1A1HPGD | |
| SCHEMBL4094402 | 0.81 | FGFR4 (0.43) | CSNK1DFGFR1MAPK14SMOFGFR4 | |
| SCHEMBL13811905 | 0.79 | CSNK1D (0.56) | CSNK1DJAK2LRRK2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065383-A1 | Indazole compounds and methods of use thereof as protein kinase inhibitors | Signal Pharmaceuticals, Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | BHAGWAT SHRIPAD S | 2009-04-16 | — | — | US | disclosed |
| US-20060004043-A1 | Indazole compounds and methods of use thereof | BHAGWAT SHRIPAD S | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | WNT3, WNT3A, WNK3 | CSNK1D 702/4885FGFR1 827/4885PRKDC 492/4885 |
| US-20060004043-A1 | Indazole compounds and methods of use thereof | WNT3, WNT3A, WNK3 | CSNK1D 687/4885FGFR1 791/4885PRKDC 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.