Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 4/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.30 |
| ▸ | FNTA | P49354 | 2/20 | 0.30 |
| ▸ | FNTB | P49356 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724954 | 0.81 | MAPK1 (0.54) | ABHD6MAPK1MAPTFNTAFNTB | |
| SCHEMBL14995412 | 0.78 | ABHD6 (0.38) | ABHD6HPGDHTTALDH1A1 | |
| SCHEMBL13320471 | 0.77 | BRD4 (0.33) | NNMTPIK3C3GRM5 | |
| SCHEMBL723952 | 0.75 | ABHD6 (0.49) | ABHD6HPGDHTTSMN1; SMN2GRM5 | |
| Bromide SCHEMBL2844387 | 0.75 | BRD4 (0.32) | NNMTGRM5 | |
| SCHEMBL725593 | 0.75 | IDH1 (0.40) | BRS3L3MBTL1MAPK1 | |
| SCHEMBL2844900 | 0.74 | MAPK1 (0.46) | ABHD6HPGDMAPK1MAPTFNTA | |
| SCHEMBL2843141 | 0.74 | ESR1 (0.36) | NNMTHPGDALDH1A1FNTAFNTB | |
| SCHEMBL2843054 | 0.74 | HTR3E (0.39) | SMN1; SMN2GRM5MAPT | |
| SCHEMBL21591731 | 0.73 | ABHD6 (0.59) | ABHD6HPGDHTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054422-A1 | ACRYLAMIDE DERIVATIVES AS FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008009122-A1 | ACRYLAMIDE DERIVATIVES AS FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2008-01-24 | — | — | WO | disclosed |