Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274420 | 0.89 | PARP1 (0.72) | PARP1KMOCA12CA1CA2 | |
| SCHEMBL14997104 | 0.86 | PARP1 (0.56) | PARP1KMOCA12CA1CA2 | |
| SCHEMBL7999629 | 0.85 | PARP1 (0.55) | PARP1KMOCA12CA1CA2 | |
| Phenol SCHEMBL28650467 | 0.81 | PARP1 (0.62) | PARP1KMOCA12CA1CA2 | |
| Aniline SCHEMBL28655458 | 0.80 | PARP1 (0.65) | PARP1KMOCA12CA1CA2 | |
| SCHEMBL1556706 | 0.77 | DRD3 (0.51) | PARP1CA12CA2CA9TSHR | |
| SCHEMBL18907044 | 0.77 | KMO (0.65) | PARP1KMOCA12CA1CA2 | |
| SCHEMBL528466 | 0.75 | TSHR (0.70) | TSHRKMT2AMEN1 | |
| SCHEMBL1499340 | 0.73 | PARP1 (0.70) | PARP1KMOTSHRALDH1A1KMT2A | |
| SCHEMBL30004753 | 0.73 | PARP1 (1.00) | PARP1TSHRHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044004-A2 | BENZAMIDE DERIVATIVES AS MODULATORS OF 11BETA-HSD1 FOR TREATING DIABETES AND OBESITY | Amgen Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007145835-A2 | BENZAMIDE DERIVATIVES AS MODULATORS OF 11BETA-HSD1 FOR TREATING DIABETES AND OBESITY | AMGEN INC. (US) | 2007-12-21 | — | — | WO | disclosed |