Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073644 | 0.84 | OPRM1 (0.53) | OPRM1OPRK1OPRD1HDAC1F3 | |
| SCHEMBL1347785 | 0.83 | FYN (0.45) | OPRM1OPRK1OPRD1HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL4073979 | 0.83 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1F3 | |
| SCHEMBL4083769 | 0.82 | OPRM1 (0.42) | OPRM1OPRK1OPRD1HDAC1HDAC6 | |
| SCHEMBL13633134 | 0.80 | OPRK1 (0.41) | OPRM1OPRK1OPRD1HDAC1HDAC8 | |
| Hydrochloric Acid SCHEMBL4072865 | 0.80 | OPRK1 (0.40) | OPRM1OPRK1OPRD1HDAC1HDAC8 | |
| SCHEMBL27764617 | 0.80 | OPRM1 (0.46) | OPRM1OPRK1OPRD1S1PR1HDAC1 | |
| SCHEMBL4079230 | 0.80 | OPRM1 (0.40) | OPRM1OPRK1OPRD1HDAC1F3 | |
| SCHEMBL4075641 | 0.79 | OPRM1 (0.52) | OPRM1OPRK1OPRD1HDAC1HDAC8 | |
| SCHEMBL4078534 | 0.79 | OPRM1 (0.41) | OPRM1OPRK1OPRD1HDAC1F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101583593-A | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER PROD INC (US) | 2009-11-18 | — | — | CN | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |
| CN-101583593-A | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER PROD INC (US) | 2009-11-18 | — | — | CN | disclosed |