Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | QDPR | P09417 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.37 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962643 | 0.99 | HTR1D (0.49) | HTR1DHTR1BGAAMAPTKDM4E | |
| SCHEMBL4562943 | 0.99 | HTR1D (0.49) | HTR1DHTR1BGAAMAPTKDM4E | |
| SCHEMBL25565747 | 0.85 | CHRM4 (0.43) | HTR1DHTR1BGAAMAPTKDM4E | |
| SCHEMBL23978364 | 0.84 | ADRA2A (0.47) | HTR1DHTR1BKCNH2QDPRSSTR4 | |
| SCHEMBL282999 | 0.82 | QDPR (0.52) | HTR1DHTR1BGAAMAPTQDPR | |
| SCHEMBL30496473 | 0.82 | QDPR (0.52) | HTR1DHTR1BGAAMAPTQDPR | |
| SCHEMBL30020108 | 0.79 | HTR1D (0.49) | HTR1DHTR1BMAPTKDM4EKCNH2 | |
| SCHEMBL20899575 | 0.77 | MAPT (0.47) | GAAMAPTKDM4ETP53TRPC6 | |
| SCHEMBL26040667 | 0.77 | HTR1D (0.52) | HTR1DHTR1BMAPTKDM4EQDPR | |
| SCHEMBL10036163 | 0.76 | HTR1D (0.49) | HTR1DHTR1BQDPRDRD2HTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | disclosed |
| EP-2084134-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008056148-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | CSF1R, CSF3R, FLT3 | HTR1D 3252/4885HTR1B 3668/4885GAA 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.