Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Goserelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR known ✓ | P30968 | 2/20 | 0.62 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.54 |
| ▸ | APLNR | P35414 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Goserelin SCHEMBL14193129 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL7544569 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL29833872 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL8643 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL13660188 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL25243029 | 1.00 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL6094 | 0.99 | ABCC2 (0.64) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL14485644 | 0.99 | ABCC2 (0.64) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL22367929 | 0.99 | ABCC2 (0.64) | GNRHRABCC2PTGS1C5AR1APLNR | |
| Goserelin SCHEMBL6866961 | 0.99 | GNRHR (0.63) | GNRHRABCC2PTGS1C5AR1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109394705-B | Goserelin sustained-release microsphere freeze-dried powder and preparation method thereof | 沈阳药科大学 | 2021-11-19 | — | — | CN | disclosed |
| CN-108434149-B | HSPC-sparing therapy for Rb-positive abnormal cell proliferation | G1治疗公司 | 2021-05-28 | — | — | CN | disclosed |
| US-10646572-B2 | Pharmaceutical compositions with enhanced stability | FORESEE PHARMACEUTICALS CO., LTD. (TW) | 2020-05-12 | — | — | US | disclosed |
| US-20190231881-A1 | PHARMACEUTICAL COMPOSITIONS WITH ENHANCED STABILITY | FORESEE PHARMACEUTICALS CO., LTD. (TW) | 2019-08-01 | — | — | US | disclosed |
| US-10251956-B2 | Methods of making pharmaceutical compositions with enhanced stability | FORESEE PHARMACEUTICALS CO., LTD. (TW) | 2019-04-09 | — | — | US | disclosed |
| US-20180050108-A1 | Methods of Making Pharmaceutical Compositions with Enhanced Stability | QUEST PHARMACEUTICAL SERVICES, LLC | 2018-02-22 | — | — | US | disclosed |
| US-9744207-B2 | Pharmaceutical compositions with enhanced stability | FORESEE PHARMACEUTICALS CO., LTD. (TW) | 2017-08-29 | — | — | US | disclosed |
| US-20170119842-A1 | Pharmaceutical Compositions with Enhanced Stability | LI YUHUA (US) | 2017-05-04 | — | — | US | disclosed |
| US-9572857-B2 | Pharmaceutical compositions with enhanced stability | FORESEE PHARMACEUTICALS CO., LTD. (TW) | 2017-02-21 | — | — | US | disclosed |
| US-20160331802-A1 | Pharmaceutical Compositions with Enhanced Stability | LI YUHUA (US) | 2016-11-17 | — | — | US | disclosed |
| EP-1984009-B1 | PHARMACEUTICAL COMPOSITIONS WITH ENHANCED STABILITY | QPS LLC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-1984009-A4 | PHARMACEUTICAL COMPOSITIONS WITH ENHANCED STABILITY | QPS LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1984009-A2 | PHARMACEUTICAL COMPOSITIONS WITH ENHANCED STABILITY | QPS, LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20070196416-A1 | Pharmaceutical compositions with enhanced stability | QUEST PHARMACEUTICAL SERVICES (US) | 2007-08-23 | — | — | US | disclosed |
| WO-2007084460-A2 | PHARMACEUTICAL COMPOSITIONS WITH ENHANCED STABILITY | QPS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |