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Sugi Predict / Compounds / Goserelin

Goserelin

Goserelin

SCHEMBL7544569

CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O.CC(C)C[C@H](NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NNC(N)=O

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GNRHR

The experimentally established mechanism targets of Goserelin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GNRHR known ✓ P30968 2/20 0.63
▸ ABCC2 Q92887 1/20 0.63
▸ PTGS1 P23219 1/20 0.62
▸ C5AR1 P21730 2/20 0.55
▸ APLNR P35414 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Goserelin SCHEMBL25243029 1.00 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL14193129 1.00 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL8643 1.00 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL29833872 1.00 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL13660188 1.00 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL4080889 1.00 GNRHR (0.62) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL6094 0.99 ABCC2 (0.64) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL14485644 0.99 ABCC2 (0.64) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL22367929 0.99 ABCC2 (0.64) GNRHRABCC2PTGS1C5AR1APLNR
Goserelin SCHEMBL6866961 0.99 GNRHR (0.63) GNRHRABCC2PTGS1C5AR1APLNR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017139487-A1 METHODS, AGENTS, AND DEVICES FOR LOCAL NEUROMODULATION OF AUTONOMIC NERVES NORTHWIND MEDICAL, INC. (US) 2017-08-17 — — WO disclosed
WO-2013116061-A1 INSERTION AND REMOVAL METHODS AND APPARATUS FOR THERAPEUTIC DEVICES FORSIGHT VISION4, INC. (US) 2013-08-08 — — WO disclosed
US-20020061869-A1 Free insulin testosterone test Lichten, Edward 2002-05-23 — — US disclosed
US-6172088-B1 ADMINISTERING GONADOTROPIN RELEASING HORMONE INHIBITOR UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. 2001-01-09 — — US disclosed
EP-1032397-A1 TESTOSTERONE INHIBITORS AND USE FOR THE PROTECTION OF NEURONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2000-09-06 — — EP disclosed
WO-1999026630-A1 TESTOSTERONE INHIBITORS AND USE FOR THE PROTECTION OF NEURONS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 1999-06-03 — — WO disclosed