Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902039 | 1.00 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL7950778 | 0.93 | TP53 (0.50) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL11464933 | 0.90 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL29151515 | 0.90 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL3871705 | 0.88 | TDP1 (0.66) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL732382 | 0.87 | TDP1 (0.56) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL22754834 | 0.86 | ALDH1A1 (0.50) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL11852793 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL1680021 | 0.85 | KMT2A (0.58) | ALDH1A1TP53TSHRMAPTHPGD | |
| SCHEMBL8981438 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TP53TSHRMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115872880-A | Novel crystal form of metoprolol and preparation method thereof | 河北以岭医药研究院有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-111018724-B | Metoprolol and preparation method thereof | 江西美晶科技有限公司 | 2022-11-08 | — | — | CN | claimed |
| CN-113122057-A | Quantum dot ink and preparation method of quantum dot film | TCL集团股份有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-112645827-A | Method for continuously synthesizing metoprolol and salt thereof | 浙江普洛家园药业有限公司 | 2021-04-13 | — | — | CN | claimed |
| CN-111018724-A | Metoprolol and preparation method thereof | 江西美晶科技有限公司 | 2020-04-17 | — | — | CN | claimed |
| CN-102381995-B | Preparation method of metoprolol | YANGTZE RIVER PHARMACEUTICAL GROUP BEIJING HAIYAN PHARMACEUTICAL CO LTD | 2015-04-15 | — | — | CN | claimed |
| CN-101607918-B | Method for preparing metoprolol | BEIJING DVENTUREPHARM TECHNOLOGY DEV CO LTD | 2014-02-19 | — | — | CN | claimed |
| EP-1682081-A2 | PROCESS FOR MANUFACTURE OF METOPROLOL AND SALTS THEREOF | IPCA Laboratories Limited (IN) | 2006-07-26 | — | — | EP | claimed |
| WO-2005046568-A2 | PROCESS FOR MANUFACTURE OF METOPROLOL AND SALTS THEREOF | IPCA LABORATORIES LIMITED (IN) | 2005-05-26 | — | — | WO | claimed |
| US-20050107635-A1 | Metoprolol manufacturing process | IPCA LABORATORIES LIMITED (IN) | 2005-05-19 | — | — | US | claimed |
| EP-0942899-B1 | MANUFACTURING PROCESS OF METOPROLOL | ASTRAZENECA AB (SE) | 2003-03-12 | — | — | EP | claimed |
| US-6252113-B1 | O-ETHERIFICATION OF P-(2-METHOXYETHYL)-PHENOL WITH AQUEOUS EPICHLOROHYDRIN, EVAPORATION OF EXCESS EPICHLOROHYDRIN, DISTILLATION, THEN AMINATION WITH ISOPROPYLAMINE TO YIELD METOPROLOL PRODUCT | ASTRAZENECA AB (SE) | 2001-06-26 | — | — | US | claimed |
| EP-0942899-A1 | MANUFACTURING PROCESS OF METOPROLOL | Astra Aktiebolag (SE) | 1999-09-22 | — | — | EP | claimed |
| WO-1998022426-A1 | NEW MANUFACTURING PROCESS OF METOPROLOL | ASTRA AKTIEBOLAG (SE) | 1998-05-28 | — | — | WO | claimed |
| US-5082969-A | Industrial process for obtaining an aryloxypropanolamine | ESTEVE QUIMICA, S.A. (ES) | 1992-01-21 | — | — | US | claimed |
| US-4956284-A | Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether and/or metoprolol | GIST-BROCADES N.V. (NL) | 1990-09-11 | — | — | US | claimed |
| EP-0193228-B1 | PROCESS FOR PRODUCING OF 4-(2-METHOXYETHYL)-PHENYLGLYCIDYL ETHER AND/OR METOPROLOL | GIST-BROCADES N.V. (NL) | 1989-11-02 | — | — | EP | claimed |
| EP-0193228-A1 | Process for producing of 4-(2-methoxyethyl)-phenylglycidyl ether and/or metoprolol | GIST-BROCADES N.V. (NL) | 1986-09-03 | — | — | EP | claimed |
| US-20240034832-A1 | CURABLE COMPOSITION, CURED PRODUCT, OPTICAL MEMBER, AND OPTICAL DEVICE | DAICEL CORPORATION (JP) | 2024-02-01 | — | — | US | disclosed |
| US-3956335-A | HYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107635-A1 | Metoprolol manufacturing process | ADRB1, ADRB2, POR | ALDH1A1 535/4885TP53 4540/4885TSHR 2571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.