Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 11/20 | 0.62 |
| ▸ | CA12 | O43570 | 10/20 | 0.62 |
| ▸ | CA2 | P00918 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.62 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.62 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.62 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.62 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.62 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069104 | 0.84 | LMNA (0.70) | SMN1; SMN2RAB9ALMNAALDH1A1VCAM1 | |
| Ditolamide SCHEMBL2110790 | 0.82 | CA9 (0.64) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL13990835 | 0.81 | CA9 (0.62) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL28808612 | 0.81 | CA9 (0.62) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL414560 | 0.81 | CA9 (0.62) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL24162488 | 0.81 | KMT2A (0.74) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL2932532 | 0.81 | CA9 (0.62) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL2057514 | 0.80 | CA9 (0.66) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL17946208 | 0.79 | CA9 (0.73) | CA9CA12CA2SMN1; SMN2RAB9A | |
| SCHEMBL13990652 | 0.78 | CA9 (0.58) | CA9CA12CA2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117577-A1 | G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS | Arena Pharmaceuticals, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008085888-A1 | G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |