Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26327619 | 0.84 | LMNA (0.50) | TSHRALDH1A1CYP3A4TP53SMN1; SMN2 | |
| SCHEMBL11171940 | 0.78 | PIN1 (0.49) | TSHRTDP1L3MBTL1ALDH1A1TP53 | |
| SCHEMBL11178102 | 0.77 | NPSR1 (0.44) | TSHRALDH1A1CYP3A4TP53SMN1; SMN2 | |
| SCHEMBL8761336 | 0.75 | CHRNB2 (0.61) | TSHRTDP1L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL26327664 | 0.73 | LMNA (0.45) | TSHRTDP1L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL29042899 | 0.73 | TSHR (0.54) | TSHRTDP1L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL26325985 | 0.73 | LMNA (0.51) | TSHRALDH1A1CYP3A4TP53SMN1; SMN2 | |
| SCHEMBL31220416 | 0.72 | FABP5 (0.45) | TP53KMT2A | |
| SCHEMBL3231779 | 0.72 | KMT2A (0.41) | TSHRALDH1A1TP53SMN1; SMN2NPC1 | |
| SCHEMBL3117956 | 0.72 | TSHR (0.57) | TSHRTDP1L3MBTL1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009051910-A1 | COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-23 | — | — | WO | disclosed |