Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX2 | Q96LB1 | 5/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865984 | 0.90 | MRGPRX2 (0.62) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL3013997 | 0.90 | MRGPRX2 (0.62) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL3132180 | 0.86 | MRGPRX2 (0.63) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL8356924 | 0.86 | MRGPRX2 (0.79) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL3123600 | 0.83 | MRGPRX2 (0.62) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL28654569 | 0.82 | MRGPRX2 (0.77) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL154048 | 0.81 | MRGPRX2 (1.00) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL29583693 | 0.81 | MRGPRX2 (1.00) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL29449917 | 0.81 | MRGPRX2 (1.00) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 | |
| SCHEMBL3019720 | 0.81 | MRGPRX2 (0.61) | MRGPRX2OPRM1OPRD1OPRK1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758452-B1 | METABOLICALLY STABLE ANALGESICS AND PAIN MEDICATIONS | HUMAN BIOMOLECULAR RES INST (US) | 2017-01-25 | — | — | EP | disclosed |
| EP-1758452-A4 | SYNTHESIS OF METABOLICALLY STABLE ANALGESICS, PAIN MEDICATIONS AND OTHER AGENTS | HUMAN BIOMOLECULAR RES INST (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1758452-A1 | SYNTHESIS OF METABOLICALLY STABLE ANALGESICS, PAIN MEDICATIONS AND OTHER AGENTS | Human Biomolecular Research Institute (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005117589-A1 | SYNTHESIS OF METABOLICALLY STABLE ANALGESICS, PAIN MEDICATIONS AND OTHER AGENTS | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2005-12-15 | — | — | WO | disclosed |