Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.68 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.68 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11375185 | 0.92 | CYP4F2 (0.72) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL31477851 | 0.89 | CYP4F2 (0.69) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL3642367 | 0.87 | CYP4F2 (0.66) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL9623658 | 0.85 | CYP4F2 (0.69) | CYP4F2CYP4A11MAPTHPGDSMN1; SMN2 | |
| SCHEMBL17513472 | 0.85 | CYP4F2 (0.67) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL12035616 | 0.84 | CYP4F2 (0.75) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL9454406 | 0.83 | CYP4F2 (0.73) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL12523791 | 0.83 | CYP4F2 (0.83) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL5539853 | 0.83 | CYP4F2 (0.64) | CYP4F2CYP4A11MEP1BMAPTCA2 | |
| SCHEMBL129801 | 0.82 | CYP4F2 (0.71) | CYP4F2CYP4A11MEP1BMAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847533-B1 | SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2013-08-14 | — | — | EP | disclosed |
| US-20120149660-A1 | NOVEL N-SUBSTITUTED 5-HYDROXYPYROLLINDES AS INHIBITORS OF MDM2-P53 INTERACTIONS | LIU JIN-JUN (US) | 2012-06-14 | — | — | US | disclosed |
| WO-2012076513-A1 | 3-CYANO-1-HYDROXYMETHYL-2-PHENYLPYRROLIDINE DERIVATIVES AS INHIBITORS OF MDM2-P53 INTERACTIONS USEFUL FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-14 | — | — | WO | disclosed |
| US-7531533-B2 | 6-Membered heterocyclic compound and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-05-12 | — | — | US | disclosed |
| EP-1847533-A1 | SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2007-10-24 | — | — | EP | disclosed |
| US-20070060590-A1 | 6-Membered heterocyclic compound and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-03-15 | — | — | US | disclosed |
| WO-2003064428-A1 | FURANO- AND THIENOPYRIMIDINES AS NEUROKINASE INHIBITORS | H. LUNDBECK A/S (DK) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060590-A1 | 6-Membered heterocyclic compound and use thereof | WNT1, CYP11B2, CYP11B1 | CYP4F2 781/4885CYP4A11 56/4885MEP1B 2831/4885 |
| US-20120149660-A1 | NOVEL N-SUBSTITUTED 5-HYDROXYPYROLLINDES AS INHIBITORS OF MDM2-P53 INTERACTIONS | TP53, MDM2, TP53BP1 | CYP4F2 1977/4885CYP4A11 734/4885MEP1B 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.