Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | UNG | P13051 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20510943 | 0.80 | CNR1 (0.47) | CNR1CSF1RHDAC1HDAC6BACE1 | |
| SCHEMBL5317423 | 0.79 | HDAC1 (0.49) | ALDH1A1CYP2A6HDAC1HDAC6CHEK1 | |
| SCHEMBL346974 | 0.77 | TRIM24 (0.64) | CDK8TRIM24TRIM33CA12CA1 | |
| SCHEMBL27621710 | 0.75 | TRIM24 (0.68) | CDK8TRIM24TRIM33CA12CA1 | |
| SCHEMBL380666 | 0.75 | — | — | |
| SCHEMBL15653026 | 0.74 | IDO1 (0.58) | CDK8AXLCYP2A6CYP2D6 | |
| SCHEMBL31313039 | 0.73 | TRIM24 (0.60) | CDK8TRIM24TRIM33CA12CA1 | |
| SCHEMBL11770226 | 0.73 | TRIM24 (0.71) | CDK8TRIM24TRIM33CA12CA1 | |
| Hydrochloric Acid SCHEMBL3824245 | 0.73 | HDAC6 (0.48) | CNR1CSF1RHDAC1HDAC6BACE1 | |
| SCHEMBL237434 | 0.72 | IDO1 (0.56) | ALDH1A1CNR1BRD4CSF1RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |