Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28159654 | 0.83 | ACHE (0.52) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21799448 | 0.82 | ALDH1A1 (0.59) | ALDH1A1POLBCXCR4PARP1KDM4E | |
| SCHEMBL2687312 | 0.82 | SLC6A2 (0.52) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL994345 | 0.82 | SLC6A2 (0.52) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4696319 | 0.78 | SLC6A2 (0.51) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19918759 | 0.76 | PARP1 (0.60) | PARP1 | |
| SCHEMBL8545499 | 0.74 | PARP1 (0.41) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18580011 | 0.74 | LIPG (0.44) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18580013 | 0.74 | LIPG (0.44) | ALDH1A1POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2097947 | 0.74 | ALDH1A1 (0.40) | ALDH1A1POLBCXCR4PARP1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |