Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 13/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083815 | 0.88 | HSD11B1 (0.45) | CTSDBACE1BACE2HSD11B1 | |
| SCHEMBL4088681 | 0.85 | HSD11B1 (0.43) | HSD11B1SLC6A3 | |
| SCHEMBL4083825 | 0.83 | HSD11B1 (0.38) | HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL4078926 | 0.83 | HSD11B1 (0.38) | HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL4081766 | 0.83 | HSD11B1 (0.38) | HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL4082564 | 0.83 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL4088080 | 0.81 | CHRNA1 (0.37) | HSD11B1SLC6A3 | |
| SCHEMBL4088554 | 0.80 | CCR2 (0.39) | HSD11B1 | |
| SCHEMBL4079142 | 0.80 | HSD11B1 (0.38) | HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL4078964 | 0.79 | HSD11B1 (0.47) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |