Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL767787 | 0.83 | SMN1; SMN2 (0.45) | KDM4EADRB2ADRB1CETPMAPK1 | |
| SCHEMBL767788 | 0.83 | SMN1; SMN2 (0.45) | KDM4EADRB2ADRB1CETPMAPK1 | |
| SCHEMBL14528401 | 0.74 | CYP2D6 (0.65) | KDM4EADRB2ADRB1CYP2D6ADRB3 | |
| SCHEMBL12251503 | 0.71 | TP53 (0.49) | KDM4ECYP2D6CETPMAPK1MAPT | |
| SCHEMBL513189 | 0.71 | PTPRZ1 (0.38) | KDM4ECETPMAPK1TSHRMAPT | |
| SCHEMBL6049333 | 0.69 | CETP (0.38) | CETPMAPK1TSHR | |
| SCHEMBL513190 | 0.68 | PTPRZ1 (0.38) | CETPMAPK1TSHRMAPTHTT | |
| SCHEMBL6942017 | 0.68 | KDM4E (0.52) | KDM4EADRB2ADRB1CYP2D6MAPK1 | |
| SCHEMBL515476 | 0.66 | ACHE (0.45) | CETP | |
| SCHEMBL515475 | 0.66 | CETP (0.37) | KDM4ECETPMAPK1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |