Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078396 | 0.95 | ESR1 (0.40) | ESR1MTNR1AALDH1A1L3MBTL1TDP1 | |
| SCHEMBL4073822 | 0.92 | MAPT (0.40) | ESR1MTNR1AELANEMAPTKMT2A | |
| SCHEMBL4078497 | 0.90 | ESR1 (0.38) | ESR1MTNR1AALDH1A1L3MBTL1ELANE | |
| SCHEMBL4255377 | 0.90 | L3MBTL1 (0.42) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL4074682 | 0.88 | DHODH (0.39) | MTNR1AALDH1A1L3MBTL1MAPTKMT2A | |
| SCHEMBL4073647 | 0.88 | MAPT (0.40) | ESR1MTNR1AELANEMAPTKMT2A | |
| SCHEMBL4075828 | 0.86 | ESR1 (0.38) | ESR1MTNR1AALDH1A1L3MBTL1ELANE | |
| SCHEMBL4071784 | 0.86 | EGLN1 (0.41) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL4076022 | 0.84 | THRA (0.41) | MTNR1AALDH1A1L3MBTL1MAPTKMT2A | |
| SCHEMBL4069926 | 0.81 | MTNR1A (0.40) | ESR1MTNR1AELANEMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |