Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078006 | 0.83 | SMN1; SMN2 (0.60) | L3MBTL1SMN1; SMN2MAPTCA12CA1 | |
| SCHEMBL8278647 | 0.83 | L3MBTL1 (0.58) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL31146306 | 0.81 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL6602968 | 0.81 | CYP1A2 (0.56) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL6540259 | 0.80 | CYP1A2 (0.55) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL22990813 | 0.80 | L3MBTL1 (0.45) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL7897266 | 0.79 | L3MBTL1 (0.54) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL13602467 | 0.79 | L3MBTL1 (0.54) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL12202770 | 0.78 | AR (0.55) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL12359011 | 0.78 | EPHX2 (0.43) | L3MBTL1CYP1A2CYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190002420-A1 | PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2019-01-03 | — | — | US | disclosed |
| US-8507479-B2 | — | — | 2013-08-13 | — | — | US | disclosed |
| US-8168630-B2 | Aminodihydrothiazine derivatives substituted with a cyclic group | SHIONOGI & CO., LTD. (JP) | 2012-05-01 | — | — | US | disclosed |
| US-8168630-B2 | Aminodihydrothiazine derivatives substituted with a cyclic group | SHIONOGI & CO., LTD. (JP) | 2012-05-01 | — | — | US | disclosed |
| US-20100075957-A1 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP | SHIONOGI & CO., LTD. (JP) | 2010-03-25 | — | — | US | disclosed |
| US-20100075957-A1 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP | SHIONOGI & CO., LTD. (JP) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075957-A1 | AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED WITH A CYCLIC GROUP | APP, IAPP, APBA1 | L3MBTL1 1241/4885CYP1A2 385/4885CYP2C9 1472/4885 |
| US-20190002420-A1 | PROCESS AND INTERMEDIATES FOR PREPARATION OF THIAZINE DERIVATIVES | CYP11B2, CYP11B1, DHPS | L3MBTL1 4311/4885CYP1A2 69/4885CYP2C9 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.