Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | AR | P10275 | 7/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | PGR | P06401 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082890 | 1.00 | MEN1 (0.63) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL5925193 | 0.84 | PGR (0.70) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL149089 | 0.84 | PGR (0.70) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL4415818 | 0.82 | MEN1 (0.60) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL4407552 | 0.82 | MEN1 (0.60) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL20843739 | 0.81 | AR (0.72) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL1405853 | 0.80 | NR3C1 (0.73) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL8000538 | 0.80 | NR3C1 (0.73) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL1406037 | 0.80 | NR3C1 (0.73) | MEN1KMT2AARNR3C1CYP3A4 | |
| SCHEMBL1405851 | 0.80 | NR3C1 (0.73) | MEN1KMT2AARNR3C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2749278-A1 | Gestagen combination and an insulin sensitizer for treating PCOS | Richter Gedeon NYRT (HU) | 2014-07-02 | — | — | EP | disclosed |
| US-20090118245-A1 | MEDICAMENT | GRUNENTHAL GMBH (DE) | 2009-05-07 | — | — | US | disclosed |
| EP-2029129-A1 | GESTAGEN COMBINATION AND AN INSULIN SENSITIZER FOR TREATING PCOS | Grünenthal GmbH (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007137797-A1 | GESTAGEN COMBINATION AND AN INSULIN SENSITIZER FOR TREATING PCOS | Grünenthal GmbH (DE) | 2007-12-06 | — | — | WO | disclosed |