Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.51 |
| ▸ | AR | P10275 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.51 |
| ▸ | PGR | P06401 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407552 | 1.00 | MEN1 (0.60) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL4082890 | 0.82 | MEN1 (0.63) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL4082888 | 0.82 | MEN1 (0.63) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL149089 | 0.81 | PGR (0.70) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL5925193 | 0.81 | PGR (0.70) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL10390405 | 0.77 | MEN1 (0.64) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL9169846 | 0.75 | MEN1 (1.00) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL11798281 | 0.73 | NR3C1 (0.67) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL10860460 | 0.73 | NR3C1 (0.67) | MEN1KMT2ANR3C1ARCYP3A4 | |
| SCHEMBL9168274 | 0.73 | NR3C1 (0.67) | MEN1KMT2ANR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8465763-B2 | 3-hydroxychlormadinone acetate for the topical treatment of androgen-dependent skin diseases | RICHTER GEDEON NYRT. (HU) | 2013-06-18 | — | — | US | claimed |
| EP-2124924-B1 | Active ingredient combination of a retinoid and a hormone combination with contraceptive action as medicament for treatment of skin diseases | GRUENENTHAL GMBH (DE) | 2012-06-27 | — | — | EP | claimed |
| US-20090318395-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | GRUNENTHAL GMBH (DE) | 2009-12-24 | — | — | US | claimed |
| US-20090312296-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | GRUNENTHAL GMBH (DE) | 2009-12-17 | — | — | US | claimed |
| EP-2124924-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | Grünenthal GmbH (DE) | 2009-12-02 | — | — | EP | claimed |
| EP-2124960-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2009-12-02 | — | — | EP | claimed |
| WO-2008077542-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2008-07-03 | — | — | WO | claimed |
| WO-2008077541-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | Grünenthal GmbH (DE) | 2008-07-03 | — | — | WO | claimed |
| US-20140249117-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | RICHTER GEDEON NYRT. (HU) | 2014-09-04 | — | — | US | disclosed |
| US-8465763-B2 | 3-hydroxychlormadinone acetate for the topical treatment of androgen-dependent skin diseases | RICHTER GEDEON NYRT. (HU) | 2013-06-18 | — | — | US | disclosed |
| US-8465763-B2 | 3-hydroxychlormadinone acetate for the topical treatment of androgen-dependent skin diseases | RICHTER GEDEON NYRT. (HU) | 2013-06-18 | — | — | US | disclosed |
| EP-2124924-B1 | Active ingredient combination of a retinoid and a hormone combination with contraceptive action as medicament for treatment of skin diseases | GRUENENTHAL GMBH (DE) | 2012-06-27 | — | — | EP | disclosed |
| US-20090318395-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | GRUNENTHAL GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| US-20090318395-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | GRUNENTHAL GMBH (DE) | 2009-12-24 | — | — | US | disclosed |
| EP-2124924-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | Grünenthal GmbH (DE) | 2009-12-02 | — | — | EP | disclosed |
| EP-2124960-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2009-12-02 | — | — | EP | disclosed |
| EP-2124960-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077541-A1 | ACTIVE INGREDIENT COMBINATION OF A RETINOID AND A HORMONE COMBINATION WITH CONTRACEPTIVE ACTION AS MEDICAMENT FOR TREATMENT OF SKIN DISEASES | Grünenthal GmbH (DE) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008077542-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008077542-A1 | 3-HYDROXYCHLORMADINONE ACETATE FOR THE TOPICAL TREATMENT OF ANDROGEN-DEPENDENT SKIN DISEASES | Grünenthal GmbH (DE) | 2008-07-03 | — | — | WO | disclosed |