Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088217 | 0.91 | AURKA (0.51) | AURKAJAK2FGFR1FGFR3MAPK1 | |
| SCHEMBL4088609 | 0.91 | AURKA (0.49) | AURKACDC7MAP4K4CLK2DYRK1A | |
| SCHEMBL4088617 | 0.87 | CDK7 (0.46) | AURKACDC7MAP4K4CLK2DYRK1A | |
| SCHEMBL4092679 | 0.85 | AURKA (0.49) | AURKACDC7CLK2DYRK1ADAPK3 | |
| SCHEMBL4083477 | 0.85 | AURKA (0.42) | AURKAPAK4MAPK1TP53SMN1; SMN2 | |
| SCHEMBL4088455 | 0.84 | AURKA (0.47) | AURKAFGFR1FGFR3MAPK1CDK7 | |
| SCHEMBL4078750 | 0.84 | AURKA (0.45) | AURKAFGFR1FGFR3MAPK1CDK7 | |
| SCHEMBL4088257 | 0.84 | AURKA (0.47) | AURKACDC7DYRK3MAP4K4RPS6KB1 | |
| SCHEMBL4084047 | 0.84 | AURKA (0.42) | AURKAFGFR1FGFR3CDK7CCNA2 | |
| SCHEMBL4091567 | 0.83 | AURKA (0.48) | AURKAFGFR1FGFR3FLT3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |