Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 10/20 | 0.46 |
| ▸ | KIT | P10721 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082917 | 0.93 | AURKA (0.48) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4088217 | 0.91 | AURKA (0.51) | AURKAABL1BCRFGFR1FGFR2 | |
| SCHEMBL4083473 | 0.90 | PDE2A (0.47) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4088609 | 0.89 | AURKA (0.49) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4092679 | 0.89 | AURKA (0.49) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4088617 | 0.87 | CDK7 (0.46) | AURKAFLT3NPC1RAB9AROCK2 | |
| SCHEMBL4085444 | 0.86 | AURKA (0.47) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4081022 | 0.85 | FLT3 (0.50) | FLT3KITNPC1RAB9AATM | |
| SCHEMBL4081942 | 0.85 | KIT (0.54) | AURKAFLT3KITABL1BCR | |
| SCHEMBL4078750 | 0.84 | AURKA (0.45) | AURKAABL1BCRFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |