Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.39 |
| ▸ | CDK7 | P50613 | 6/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850096 | 0.91 | AURKA (0.39) | AURKAHDAC6FGFR1FGFR2FGFR3 | |
| SCHEMBL4082088 | 0.89 | SMN1; SMN2 (0.41) | HTT | |
| SCHEMBL4088217 | 0.88 | AURKA (0.51) | AURKAHDAC6FGFR1FGFR2FGFR3 | |
| SCHEMBL4091695 | 0.88 | MAPK1 (0.45) | — | |
| SCHEMBL653335 | 0.87 | FADS1 (0.36) | AURKAHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL4088412 | 0.86 | ABL1 (0.51) | AURKAFGFR1NTRK1 | |
| SCHEMBL4082899 | 0.86 | AURKA (0.60) | AURKANTRK1 | |
| SCHEMBL653354 | 0.86 | RXFP1 (0.38) | — | |
| SCHEMBL4086294 | 0.86 | ABL1 (0.52) | AURKAFGFR1NTRK1 | |
| SCHEMBL4093460 | 0.86 | AURKA (0.48) | AURKAHDAC6NTRK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |