Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | USP36 | Q9P275 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088217 | 0.93 | AURKA (0.51) | AURKAUSP36ABL1BCRHDAC6 | |
| SCHEMBL4083527 | 0.91 | HDAC6 (0.42) | AURKAHDAC6CDC7DAPK3PAK4 | |
| SCHEMBL4088609 | 0.90 | AURKA (0.49) | AURKAUSP36ABL1BCRHDAC6 | |
| SCHEMBL4082917 | 0.89 | AURKA (0.48) | AURKAABL1BCRHDAC6CDK2 | |
| SCHEMBL4091567 | 0.89 | AURKA (0.48) | AURKAABL1BCRFLT3NPC1 | |
| SCHEMBL4085444 | 0.88 | AURKA (0.47) | AURKAABL1BCRHDAC6CDC7 | |
| SCHEMBL4083473 | 0.86 | PDE2A (0.47) | AURKAABL1BCRHDAC6FLT3 | |
| SCHEMBL4088416 | 0.86 | LMNA (0.42) | AURKAABL1NPC1MAPTRAB9A | |
| SCHEMBL4092903 | 0.86 | ABL1 (0.61) | AURKAABL1BCRHDAC6CDC7 | |
| SCHEMBL4083868 | 0.86 | ABL1 (0.59) | AURKAABL1BCRCDC7PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |