Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 3/20 | 0.41 |
| ▸ | MTTP | P55157 | 2/20 | 0.41 |
| ▸ | APOB | P04114 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12650844 | 0.93 | HDAC1 (0.50) | HDAC1HDAC8HDAC6PRMT5SMO | |
| Trifluoroacetic Acid SCHEMBL1790201 | 0.85 | SLC2A1 (0.58) | HDAC1SLC2A1PRMT5SMOMTTP | |
| Trifluoroacetic Acid SCHEMBL3345294 | 0.85 | CCR6 (0.43) | HDAC1HDAC8HDAC6FLT1CDC7 | |
| Trifluoroacetic Acid SCHEMBL3345474 | 0.83 | SLC2A1 (0.46) | HDAC1SLC2A1PRMT5MTTPAPOB | |
| Trifluoroacetic Acid SCHEMBL3345140 | 0.82 | OPRM1 (0.53) | HDAC1HDAC8SLC2A1PRMT5F11 | |
| Trifluoroacetic Acid SCHEMBL3339839 | 0.82 | OPRM1 (0.56) | HDAC1SLC2A1PRMT5SMOOPRM1 | |
| SCHEMBL3339104 | 0.81 | HDAC1 (0.51) | HDAC1HDAC8HDAC6SLC2A1SMO | |
| Trifluoroacetic Acid SCHEMBL3345226 | 0.79 | GRIN2B (0.50) | HDAC1HDAC8SLC2A1PRMT5F11 | |
| SCHEMBL4082951 | 0.79 | HDAC1 (0.48) | HDAC1HDAC8HDAC6PRMT5SMO | |
| SCHEMBL4075715 | 0.79 | HDAC1 (0.48) | HDAC1HDAC8HDAC6PRMT5SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | HDAC1 1478/4885HDAC8 1607/4885HDAC6 1760/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | HDAC1 2440/4885HDAC8 2033/4885HDAC6 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.