Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29423627 | 0.84 | DNMT1 (0.55) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL137604 | 0.84 | DNMT1 (0.55) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL29262283 | 0.82 | DNMT1 (0.53) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| Phenanthrene SCHEMBL28161136 | 0.77 | CYP2A6 (0.55) | ALDH1A1CYP1A2HIF1ACA12CA9 | |
| Maleic Anhydride SCHEMBL29199820 | 0.76 | DNMT1 (0.47) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL15119562 | 0.76 | ALDH1A1 (0.59) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4075535 | 0.74 | DNMT1 (0.40) | DNMT1MAPTMEN1KMT2AALDH1A1 | |
| Triphenylene SCHEMBL2841244 | 0.73 | GPR3 (0.48) | MAPTALDH1A1CYP1A2HPGDCA12 | |
| SCHEMBL7981169 | 0.73 | TYMS (0.38) | DNMT1TYMSALOX15TDP1 | |
| SCHEMBL7985135 | 0.73 | TYMS (0.48) | DNMT1MAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114702509-B | Benzothiophene naphthalimide derivative and synthesis process and application thereof | 浙江工业大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-114702509-A | Benzothienonaphthalimide derivative and synthesis process and application thereof | 浙江工业大学 | 2022-07-05 | — | — | CN | disclosed |
| EP-1626050-B1 | SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES | UNIV EAST CHINA SCIENCE & TECH (CN) | 2009-12-02 | — | — | EP | disclosed |
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE (CN) | 2006-05-25 | — | — | US | disclosed |
| EP-1626050-A1 | SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES | East China University of Science and Technology (CN) | 2006-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | HCCS, SQOR, MKI67 | DNMT1 2041/4885MAPT 4558/4885MEN1 3613/4885 |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | HCCS, SQOR, MKI67 | DNMT1 2041/4885MAPT 4558/4885MEN1 3613/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.