Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.59 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3499130 | 0.88 | GABRA2 (0.62) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL21033153 | 0.88 | GABRA2 (0.62) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL24066036 | 0.85 | KDM4E (0.60) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL3498049 | 0.85 | KDM4E (0.55) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL3660875 | 0.84 | EGLN1 (0.67) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL3774418 | 0.84 | CYP2C9 (0.56) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL21033565 | 0.84 | KDM4E (0.57) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL3767161 | 0.84 | NR4A2 (0.61) | KDM4EPOLBGABRA2GABRB2ALDH1A1 | |
| SCHEMBL3499671 | 0.84 | SCN5A (0.58) | KDM4EPOLBEGLN1GABRA2GABRB2 | |
| SCHEMBL21033468 | 0.83 | KDM4E (0.56) | KDM4EPOLBEGLN1GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210371431-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | JUBILANT EPISCRIBE LLC | 2021-12-02 | — | — | US | disclosed |
| WO-2019102494-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | JUBILANT BIOSYS LIMITED (IN) | 2019-05-31 | — | — | WO | disclosed |
| US-8288424-B2 | Substituted tetrahydroimidazopyridine compounds and the use thereof in the treatment of pain and other conditions | GRUENENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-8288424-B2 | Substituted tetrahydroimidazopyridine compounds and the use thereof in the treatment of pain and other conditions | GRUENENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| WO-2009092565-A1 | SUBSTITUTED TETRAHYDROIMIDAZOPYRIDINE COMPOUNDS AND THE USE THEREOF IN PHARMACEUTICALS | Grünenthal GmbH (DE) | 2009-07-30 | — | — | WO | disclosed |
| US-20090186902-A1 | Substituted Tetrahydroimidazopyridine Compounds and the Use Thereof in the Treatment of Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2009-07-23 | — | — | US | disclosed |
| US-20090186902-A1 | Substituted Tetrahydroimidazopyridine Compounds and the Use Thereof in the Treatment of Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210371431-A1 | HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | KDM4E 221/4885POLB 1269/4885EGLN1 3080/4885 |
| US-20090186902-A1 | Substituted Tetrahydroimidazopyridine Compounds and the Use Thereof in the Treatment of Pain and Other Conditions | HRH4, TRPV1, QDPR | KDM4E 1006/4885POLB 3927/4885EGLN1 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.