Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082917 | 0.90 | AURKA (0.48) | AURKAHDAC6FLT3NPC1RAB9A | |
| SCHEMBL4091567 | 0.90 | AURKA (0.48) | AURKAFLT3NPC1RAB9AABL1 | |
| SCHEMBL4088217 | 0.89 | AURKA (0.51) | AURKAHDAC6MAPK1ABL1BCR | |
| SCHEMBL4088609 | 0.88 | AURKA (0.49) | AURKAHDAC6FLT3NPC1RAB9A | |
| SCHEMBL4092679 | 0.86 | AURKA (0.49) | AURKAHDAC6FLT3NPC1RAB9A | |
| SCHEMBL4082126 | 0.85 | HDAC6 (0.48) | HDAC6TRPV1MTORCTNNB1TCF7L2 | |
| SCHEMBL4085444 | 0.84 | AURKA (0.47) | AURKAHDAC6CTNNB1TCF7L2FLT3 | |
| SCHEMBL4088617 | 0.83 | CDK7 (0.46) | AURKAHDAC6FLT3NPC1RAB9A | |
| SCHEMBL4082950 | 0.83 | AURKA (0.44) | AURKAFLT3MAPK8NPC1RAB9A | |
| SCHEMBL4081942 | 0.83 | KIT (0.54) | AURKAFLT3ABL1BCRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |