Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | BCR | P11274 | 2/20 | 0.59 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092903 | 0.98 | ABL1 (0.61) | ABL1BCRAURKAACKR3HIF1A | |
| SCHEMBL4093502 | 0.97 | ABL1 (0.63) | ABL1BCRAURKAACKR3HIF1A | |
| SCHEMBL4081436 | 0.94 | AURKA (0.57) | ABL1BCRAURKAACKR3HIF1A | |
| SCHEMBL4081465 | 0.94 | ABL1 (0.54) | ABL1BCRAURKAHIF1AEPAS1 | |
| SCHEMBL4088412 | 0.88 | ABL1 (0.51) | ABL1BCRAURKAHIF1AEPAS1 | |
| SCHEMBL4086294 | 0.87 | ABL1 (0.52) | ABL1BCRAURKAHIF1AEPAS1 | |
| SCHEMBL4088217 | 0.87 | AURKA (0.51) | ABL1BCRAURKAJAK2FGFR1 | |
| SCHEMBL4092679 | 0.86 | AURKA (0.49) | ABL1BCRAURKAACKR3KDM4E | |
| SCHEMBL4082984 | 0.86 | AURKA (0.48) | ABL1BCRAURKAKITFLT3 | |
| SCHEMBL4078156 | 0.85 | KDR (0.45) | ABL1BCRAURKAHIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |