Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086294 | 0.99 | ABL1 (0.52) | ABL1BCRHRH3CYP2C9AURKA | |
| SCHEMBL4093460 | 0.94 | AURKA (0.48) | ABL1BCRAURKADYRK1AKDR | |
| SCHEMBL4088344 | 0.94 | RAB9A (0.46) | ABL1BCRAURKAKDRHIF1A | |
| SCHEMBL4092903 | 0.90 | ABL1 (0.61) | ABL1BCRHRH3CYP2C9AURKA | |
| SCHEMBL4093502 | 0.89 | ABL1 (0.63) | ABL1BCRHRH3CYP2C9AURKA | |
| SCHEMBL4081802 | 0.88 | FLT3 (0.43) | ABL1BCRAURKADYRK1AKDR | |
| SCHEMBL4083868 | 0.88 | ABL1 (0.59) | ABL1BCRHRH3CYP2C9AURKA | |
| SCHEMBL13850096 | 0.87 | AURKA (0.39) | ABL1BCRAURKADYRK1AFLT3 | |
| SCHEMBL4084047 | 0.86 | AURKA (0.42) | AURKANTRK1FGFR1 | |
| SCHEMBL4082899 | 0.84 | AURKA (0.60) | ABL1BCRAURKAKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |