Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084587 | 0.84 | HSD11B1 (0.35) | HSD11B1HSD11B2 | |
| SCHEMBL4094477 | 0.79 | CHRNA1 (0.43) | SIGMAR1JAK3KMT2AFAAHCNR2 | |
| SCHEMBL75123 | 0.72 | HSD11B1 (0.49) | HSD11B1JAK3CHRM2CHRM4CHRM5 | |
| SCHEMBL4078865 | 0.70 | HSD11B1 (0.45) | HSD11B1SIGMAR1JAK3CHRM2CHRM4 | |
| SCHEMBL24287884 | 0.68 | SIGMAR1 (0.50) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31027152 | 0.62 | CNR2 (0.48) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL647856 | 0.62 | CNR2 (0.48) | SIGMAR1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL12012564 | 0.61 | HSD11B1 (0.53) | HSD11B1JAK3KMT2AHSD11B2MEN1 | |
| SCHEMBL12012576 | 0.61 | HSD11B1 (0.53) | HSD11B1JAK3KMT2AHSD11B2MEN1 | |
| SCHEMBL2170319 | 0.61 | HSD11B1 (0.53) | HSD11B1JAK3KMT2AHSD11B2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |