Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1364921 | 1.00 | HDAC3 (0.46) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1364924 | 1.00 | HDAC3 (0.46) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1364922 | 1.00 | HDAC3 (0.46) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1365108 | 0.90 | MAP4K4 (0.50) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1366923 | 0.86 | RIPK1 (0.46) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1365962 | 0.86 | HPGDS (0.41) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1366021 | 0.84 | DRD2 (0.52) | HPGDSDRD2DRD4MAP4K4GRM5 | |
| SCHEMBL2071103 | 0.78 | HPGDS (0.56) | HPGDSMAP4K4GABRA5 | |
| SCHEMBL2071101 | 0.78 | HPGDS (0.56) | HPGDSMAP4K4GABRA5 | |
| SCHEMBL2071106 | 0.78 | HPGDS (0.56) | HPGDSMAP4K4GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582643-B2 | Heterocyclic compounds useful in treating diseases and conditions | PFIZER INC (US) | 2009-09-01 | — | — | US | disclosed |