Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.71 |
| ▸ | ABL1 | P00519 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653338 | 0.95 | AURKA (0.65) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4081182 | 0.92 | AURKA (0.61) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4081915 | 0.91 | AURKA (0.62) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4088635 | 0.90 | AURKA (0.58) | AURKAKITFLT3 | |
| SCHEMBL4082899 | 0.90 | AURKA (0.60) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4081436 | 0.89 | AURKA (0.57) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4088217 | 0.87 | AURKA (0.51) | AURKAABL1BCR | |
| SCHEMBL3881539 | 0.86 | AURKA (0.60) | AURKAKITFLT3 | |
| SCHEMBL4081942 | 0.85 | KIT (0.54) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL650431 | 0.85 | AURKA (0.54) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |