Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 5/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4093460 | 0.90 | AURKA (0.48) | AURKANTRK1INSRIGF1RAURKB | |
| SCHEMBL4086497 | 0.90 | AURKA (0.71) | AURKAKITFLT3ABL1BCR | |
| SCHEMBL653322 | 0.89 | ALK (0.54) | AURKANTRK1INSRIGF1RAURKB | |
| SCHEMBL654874 | 0.87 | AURKA (0.46) | AURKANTRK1INSRIGF1RAURKB | |
| SCHEMBL4084047 | 0.86 | AURKA (0.42) | AURKANTRK1 | |
| SCHEMBL653338 | 0.85 | AURKA (0.65) | AURKAKITFLT3ABL1BCR | |
| SCHEMBL4088344 | 0.84 | RAB9A (0.46) | AURKAFLT3ABL1BCR | |
| SCHEMBL4081915 | 0.84 | AURKA (0.62) | AURKANTRK1INSRIGF1RAURKB | |
| SCHEMBL4088412 | 0.84 | ABL1 (0.51) | AURKANTRK1INSRAURKBKIT | |
| SCHEMBL4086294 | 0.83 | ABL1 (0.52) | AURKANTRK1INSRIGF1RAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |