Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4086497 | 0.92 | AURKA (0.71) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4086831 | 0.89 | AURKA (0.54) | AURKAKITFLT3KDRNTRK1 | |
| SCHEMBL4081465 | 0.89 | ABL1 (0.54) | AURKAABL1BCRFLT3KDR | |
| SCHEMBL653338 | 0.88 | AURKA (0.65) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4088217 | 0.87 | AURKA (0.51) | AURKAABL1BCRJAK2FGFR1 | |
| SCHEMBL4088609 | 0.85 | AURKA (0.49) | AURKAABL1BCRFLT3NTRK1 | |
| SCHEMBL4092679 | 0.85 | AURKA (0.49) | AURKAABL1BCRFLT3CDC7 | |
| SCHEMBL3881571 | 0.85 | AURKA (0.61) | AURKAKITFLT3KDRNTRK1 | |
| SCHEMBL18108801 | 0.84 | AURKA (0.60) | AURKAABL1BCRKITFLT3 | |
| SCHEMBL4092903 | 0.84 | ABL1 (0.61) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |