Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64650 | 0.78 | BACE1 (0.49) | MPONOS1KCNH2ALDH1A1 | |
| SCHEMBL2154019 | 0.78 | GLA (0.53) | NOS1HRH3CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3939288 | 0.77 | MPO (0.46) | MPONOS1HRH3CYP19A1CYP11B1 | |
| SCHEMBL63824 | 0.74 | TAAR1 (0.54) | — | |
| SCHEMBL4010143 | 0.73 | FOLH1 (0.46) | CYP4F2CYP4A11 | |
| SCHEMBL9878817 | 0.72 | HRH3 (0.46) | MPONOS1HRH3CYP19A1CYP11B1 | |
| SCHEMBL6950852 | 0.72 | TSHR (0.52) | HRH3CYP19A1CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL63191 | 0.72 | CYP2A6 (0.51) | MPOHRH3NOS2 | |
| SCHEMBL6420561 | 0.72 | ADRA2C (0.47) | NOS1HRH3CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL3939419 | 0.71 | CYP4F2 (0.54) | MPOCYP4F2CYP4A11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |