SCHEMBL4087331

SCHEMBL4087331

Clc1ccc(-c2nc(Cl)nc3ccccc23)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.75
ALDH1A1 P00352 3/20 0.75
LMNA P02545 3/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
GAA P10253 1/20 0.61
ATM Q13315 2/20 0.57
POLB P06746 1/20 0.57
MAPK1 P28482 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
MAPT P10636 1/20 0.54
ADORA2A P29274 2/20 0.50
GLA P06280 1/20 0.50
HPGD P15428 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
NUDT1 P36639 1/20 0.50
THRB P10828 1/20 0.49
TNKS O95271 1/20 0.49
GUSB P08236 1/20 0.49
TNKS2 Q9H2K2 1/20 0.49
PARP2 Q9UGN5 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL808191 0.91 KDM4E (0.77) KDM4EALDH1A1LMNAL3MBTL1GAA
SCHEMBL17286874 0.91 KDM4E (0.77) KDM4EALDH1A1LMNAL3MBTL1GAA
SCHEMBL808420 0.90 KDM4E (0.77) KDM4EALDH1A1LMNAL3MBTL1GAA
Hydrochloric Acid SCHEMBL5803147 0.87 KDM4E (0.72) KDM4EALDH1A1LMNAL3MBTL1GAA
SCHEMBL29423640 0.86 KDM4E (1.00) KDM4EALDH1A1LMNAL3MBTL1ATM
SCHEMBL6329397 0.86 KDM4E (0.71) KDM4EALDH1A1LMNAMAPTADORA2A
SCHEMBL15860248 0.86 KDM4E (1.00) KDM4EALDH1A1LMNAL3MBTL1ATM
SCHEMBL27711581 0.86 KDM4E (0.71) KDM4EALDH1A1LMNAL3MBTL1GAA
SCHEMBL22607015 0.86 KDM4E (0.71) KDM4EALDH1A1LMNAL3MBTL1GAA
SCHEMBL5803149 0.85 KDM4E (0.70) KDM4EALDH1A1LMNAL3MBTL1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10032991-B2 Compound, organic electroluminescence element material, ink composition, organic electroluminescence element, electronic device, and method for producing compound IDEMITSU KOSAN CO., LTD. (JP) 2018-07-24 US disclosed
US-10032991-B2 Compound, organic electroluminescence element material, ink composition, organic electroluminescence element, electronic device, and method for producing compound IDEMITSU KOSAN CO., LTD. (JP) 2018-07-24 US disclosed
US-20160197288-A1 COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC DEVICE, AND METHOD FOR PRODUCING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2016-07-07 US disclosed
US-20160197288-A1 COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC DEVICE, AND METHOD FOR PRODUCING COMPOUND IDEMITSU KOSAN CO., LTD. (JP) 2016-07-07 US disclosed
US-20090062317-A1 MEDICINAL USE OF RECEPTOR LIGANDS 7TM PHARMA A/S (DK) 2009-03-05 US disclosed
EP-1778670-A2 MEDICINAL USE OF RECEPTOR LIGANDS 7TM Pharma A/S (DK) 2007-05-02 EP disclosed
WO-2006010446-A2 MEDICINAL USE OF RECEPTOR LIGANDS 7TM PHARMA A/S (DK) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160197288-A1 COMPOUND, ORGANIC ELECTROLUMINESCENCE ELEMENT MATERIAL, INK COMPOSITION, ORGANIC ELECTROLUMINESCENCE ELEMENT, ELECTRONIC DEVICE, AND METHOD FOR PRODUCING COMPOUND LEF1, L1CAM, OLA1 KDM4E 2220/4885ALDH1A1 66/4885LMNA 754/4885
US-20090062317-A1 MEDICINAL USE OF RECEPTOR LIGANDS MCHR1, MCHR2, MC1R KDM4E 3078/4885ALDH1A1 1058/4885LMNA 2850/4885
US-10032991-B2 Compound, organic electroluminescence element material, ink composition, organic electroluminescence element, electronic device, and method for producing compound LEF1, L1CAM, OLA1 KDM4E 2220/4885ALDH1A1 66/4885LMNA 754/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.