Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4163105 | 1.00 | CA12 (0.41) | CA12CA1CA2CA9PDK1 | |
| SCHEMBL29540064 | 0.81 | CA12 (0.40) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL6052943 | 0.78 | MAOB (0.40) | MAOBFKBP1A | |
| SCHEMBL28310283 | 0.78 | CA12 (0.45) | CA12CA1CA2CA9PDK1 | |
| SCHEMBL1150296 | 0.76 | CA12 (0.44) | CA12CA1CA2CA9PDK1 | |
| SCHEMBL29022309 | 0.76 | CA12 (0.44) | CA12CA1CA2CA9PDK1 | |
| SCHEMBL4140585 | 0.76 | L3MBTL1 (0.37) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL4145020 | 0.74 | L3MBTL1 (0.36) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL4156027 | 0.74 | L3MBTL1 (0.36) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL7995182 | 0.69 | CA12 (0.39) | CA12CA1CA2CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971333-A4 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-05-20 | — | — | EP | disclosed |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | LIANG CONGXIN | 2009-03-12 | — | — | US | disclosed |
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-10-30 | — | — | US | disclosed |
| EP-1971333-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | The Scripps Research Institute (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007081560-A2 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269212-A1 | Amino acid derivatives of indolinone based protein kinase inhibitors | PHKG1, MAP3K20, MKNK1 | CA12 4861/4885CA1 4648/4885CA2 3895/4885 |
| US-20090068718-A1 | AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS | PHKG1, MAP3K20, MKNK1 | CA12 4861/4885CA1 4648/4885CA2 3895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.