Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088806 | 0.96 | HSD17B13 (0.42) | CDK2ROCK2DYRK1ACDC7DAPK3 | |
| SCHEMBL4092927 | 0.85 | AURKA (0.53) | FLT3 | |
| SCHEMBL4083945 | 0.84 | MAPK1 (0.45) | CDK2DYRK1ASMN1; SMN2SCN9ACCNA2 | |
| SCHEMBL4092150 | 0.84 | SMN1; SMN2 (0.40) | CDK2DYRK1ASMN1; SMN2TP53SCN9A | |
| SCHEMBL4078233 | 0.82 | AURKA (0.54) | CDC7PAK4PRKACAFLT3JAK3 | |
| SCHEMBL4086452 | 0.80 | MAPK1 (0.46) | CDK2DYRK1ASMN1; SMN2TP53TTK | |
| SCHEMBL3879252 | 0.80 | GPR35 (0.45) | CDK2ROCK2DYRK1ACDC7DAPK3 | |
| SCHEMBL653285 | 0.80 | DYRK1A (0.41) | DYRK1ASMN1; SMN2TTKSCN9ATACR3 | |
| SCHEMBL4088328 | 0.80 | MAPK1 (0.41) | CDK2DYRK1ASMN1; SMN2TP53TTK | |
| SCHEMBL741273 | 0.78 | HSD17B13 (0.40) | CDK2ROCK2DYRK1ACDC7DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |