Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083945 | 0.96 | MAPK1 (0.45) | MAPK1DYRK1AGAAPKMAPOBEC3G | |
| SCHEMBL4088806 | 0.84 | HSD17B13 (0.42) | MAPK1DYRK1ARAB9AKDM4ENPC1 | |
| SCHEMBL653285 | 0.84 | DYRK1A (0.41) | MAPK1DYRK1AGAARAB9ANPC1 | |
| SCHEMBL4088328 | 0.84 | MAPK1 (0.41) | MAPK1DYRK1APKMRAB9AKDM4E | |
| SCHEMBL4086303 | 0.82 | MAPK1 (0.49) | MAPK1GAAPKMAPOBEC3GRAB9A | |
| SCHEMBL652665 | 0.81 | MEN1 (0.40) | DYRK1AGAARAB9AKDM4ENPC1 | |
| SCHEMBL4092150 | 0.80 | SMN1; SMN2 (0.40) | MAPK1DYRK1APKMRAB9AKDM4E | |
| SCHEMBL4088568 | 0.80 | CDK2 (0.40) | DYRK1ARAB9AKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL4078233 | 0.79 | AURKA (0.54) | — | |
| SCHEMBL742870 | 0.79 | MAPK1 (0.43) | MAPK1DYRK1AGAAPKMAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |